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apalutamide will lower the extent or outcome of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medications that are CYP2C19 substrates can result in decrease exposure to these medicines.butabarbital will lessen the extent or impact of d

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